Worm infections and their effects on general health, allergy-related conditions and metabolic parameters Infections and Infestations Helminthiasis, unspecified
Conditions
Interventions
Standard intervention against helminths (as recommended by the Vector Control Division at the Ministry of Health) comprises single-dose albendazole (400 mg) given twice-yearly to all community members
Sponsors
London School of Hygiene & Tropical Medicine (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Fishing camp villages in Koome sub-county, Mukono District, Uganda, will be eligible for inclusion. All households in participating villages will be eligible for inclusion in the surveys. In selected and participating households, all household members, of all ages, will be eligible for inclusion in the survey.
Exclusion criteria
Exclusion criteria: 1. Villages will be excluded if their Local Council leaders refuse permission for them to participate 2. Households where all members refuse to participate, or where all members are absent during the survey period 3. Does not meet inclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Original primary outcome measures (assessed in a survey after three years of anthelminthic intervention): 1. Wheeze 2. Atopy (assessed by allergen-specific serum IgE) 3. Atopy (assessed by skin prick test responses) Added 21/06/2017: Additional primary outcome measure(s) (assessed in a survey after four years of anthelminthic intervention): 1. Insulin resistance, measured using the homeostatic model assessment of Insulin resistance [HOMA-IR]. HOMA-IR = fasting serum insulin x fasting glucose / 22.5 | — |
Secondary
| Measure | Time frame |
|---|---|
| Original secondary outcome measures (assessed in a survey after three years of anthelminthic intervention): 1. Eczema (visible flexural dermatitis) 2. Helminth infection prevalence 3. Haemoglobin 4. Height and weight z-scores 5. Hepatosplenomegaly 6. Vaccine responses 7. Cognitive function in children Additional secondary outcome measures (assessed in a survey after four years of anthelminthic intervention): 1. Fasting blood glucose; plasma glucose levels measured using the enzymatic method after an overnight fast (8 hours) 2. Glycated haemoglobin, measured using the turbidimetric inhibition immunoassay (TINIA) for hemolyzed whole blood 3. Serum lipid levels (total serum cholesterol, triglyceride levels, high density lipoprotein (HDL) - cholesterol and low density lipoprotein (LDL) - cholesterol), measured using the enzymatic colorimetric method after an overnight fast (8 hours) 4. Blood pressure; the average of three blood pressure readings taken 5 minutes apart measured using a digital sphygmomanometer 5. Body mass index; body weight in kilograms measured using a weighing scale, divided by the square of height in metres measured using a stadiometer 5. Waist circumference; circumference at the mid-way position between the lowest rib and the iliac crest, recorded to the nearest 0.1 cm and measured using a non-stretchable measuring tape 6. Hip circumference; circumference at the level of the greater trochanters recorded to the nearest 0.1 cm and measured using a non-stretchable measuring tape 7. Markers of inflammation; pro- and anti-inflammatory cytokines measured using a customised immunoassay | — |
Countries
Uganda
Outcome results
None listed