Cardiovascular diseases: Heart disease Circulatory System Heart disease
Conditions
Interventions
Group 1 (control) will have angiography
Group 2 Tc-methoxyisobutylisonitrile (TcMIBI)
Group 3 Magnetic Resonance Imaging (MRI)
Group 4 will have stress echo. The referring cardiologist will have the o
Sponsors
Department of Health (UK)
Eligibility
Inclusion criteria
Inclusion criteria: Patients with chronic stable angina and a positive stress exercise test who are referred to designated Papworth cardiologists for angiography will be randomised to one of 4 groups.
Exclusion criteria
Exclusion criteria: Patients with recent (<3 months) MI, previous or urgent need for revascularisation, those known to have adverse reactions to pharmacological stress, incapable of performing ETT, pacemaker or other contraindication to MRI, not available by telephone.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure is exercise capacity: treadmill time according to modified Bruce protocol measured at baseline, at 6 months following treatment with CABG, PTCA or medical therapy and at 18 months following entry to the trial. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary measures include the Canadian Cardiovascular Society classification of angina; health related quality of life assessments: the generic SF36, disease specific Seattle Angina Questionnaire and utility EQ-5D; cardiologist's assessment of IHD risk (compared with formal risk assessment) and treatment intentions expressed prior to the diagnostic test; patients' preferences; revascularisation rate; hospital admissions for unstable angina, incidence of MI and deaths after treatment. These outcome measures will be used to evaluate the contribution of functional data to successful revascularisation. Annuitized capital costs will be calculated for each of the imaging procedures. These will be combined with running, treatment, community and patient costs in an incremental cost-effectiveness analysis. | — |
Countries
United Kingdom
Outcome results
None listed