Dextromethorphan in smoking related cough

A single centre, randomised, double blind, placebo controlled, crossover, pilot study to determine the efficacy and safety of dextromethorphan versus placebo for the treatment of smoking related cough

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN46985377

Enrollment

Registered

2003-09-12

Start date

2003-03-11

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory: Smoking related cough Respiratory Smoking related cough

Interventions

Dextromethorphan versus placebo.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 50 volunteers between 18 - 70 years.

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

Measure	Time frame
Reduction in cough frequency measured subjectively after waking on treatment day 1 over time periods 0 - 10, 10 - 20, 20 - 40 and 40 - 60 minutes.	—

Secondary

Measure	Time frame
1. Reduction in cough frequency on days 2 - 5 2. Change in cough symptoms (severity expectoration, chest pain, etc.,) and nocturnal cough 3. Change in cough threshold as measured via citric acid cough challenge	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026