Musculoskeletal Diseases: Osteoporosis Musculoskeletal Diseases Osteoporosis without pathological fracture
Conditions
Interventions
Patients will be randomly assigned to either
1. Control group,
2. Group receiving zoledronate
3. Group receiving mechanical stimulation (vibration)
and receive the treatment over a 6 month period.
Sponsors
Record Provided by the NHSTCT Register - 2004 Update - Department of Health (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients admitted to Royal National Orthopaedic Hospital (RNOH) with a spinal cord injury Added 16/04/10: 2. Female patients had to be postmenopausal, surgically sterile or willing to practice a medically acceptable form of birth control during the study period and for at least 12 months after study completion 3. All subjects gave written consent to take part in the study
Exclusion criteria
Exclusion criteria: Added 16/04/10: 1. Pregnant or breastfeeding 2. Previous history of allergic reaction to bisphosphonates 3. Previous history of iritis or uveitis 4. Significant renal impairment or evidence of vitamin D deficiency (serum 25-hydroxyvitamin D <25 nmol/L)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Changes in Bone Mineral Density and biochemical markers of bone metabolism over time. 2. Difference between groups | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed