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Testing a new treatment for receding gums

The efficiency of injectable platelet-rich fibrin (i-PRF) in root surface biomodification during gingival recession treatment

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN46963726
Enrollment
42
Registered
2021-05-13
Start date
2021-03-30
Completion date
Unknown
Last updated
2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingival recession Oral Health Gingival recession

Interventions

Participants are randomised using a sealed envelope method. Two treatment methods will be compared, the first one will involve applying a free gingival graft alone on the root surface (control group),

Sponsors

Damascus University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. =19 years of age 2. Periodontally and systemically healthy 3. Full-mouth plaque score (FMPS) and full-mouth bleeding score (FMBS) <15% 4. Presence of deep Miller Class I/II GR defect (=3 mm in depth) at the buccal aspect of incisors and canines

Exclusion criteria

Exclusion criteria: 1. Smoking 2. Contraindications for surgery 3. Presence of recession defects associated with caries, deep abrasion, restoration or pulpal pathology

Design outcomes

Primary

MeasureTime frame
1. Gingival recession depth measured using a UNC-15 probe at baseline, 1, 3, 6 months 2. Gingival recession width measured using a UNC-15 probe at baseline, 1, 3, 6 months

Secondary

MeasureTime frame
1. Probing depth measured using a UNC-15 probe at baseline, 1, 3, 6 months 2. Clinical attachment level measured using a UNC-15 probe at baseline, 1, 3, 6 months 3. Keratinized tissue height measured using a UNC-15 probe at baseline, 1, 3, 6 months 4. Healing measured using a healing index at 1, 2 weeks and 1 month after surgery 5. Pain measured using a visual analogue scale (VAS) at 1 week after surgery 6. Bleeding measured using a visual analogue scale (VAS) at 1 week after surgery 7. Dentine hypersensitivity measured using a visual analogue scale (VAS) at baseline, 1, 3, 6 months

Countries

Syria

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026