Early detection of chronic obstructive pulmonary disease (COPD) using a novel technique for assessing lung unevenness (inhomogeneity)

A novel lung function Test foR Early dETection of chronic Obstructive Pulmonary disease (COPD)

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN46851791

Enrollment

180

Registered

2024-01-17

Start date

2024-01-22

Completion date

Unknown

Last updated

2024-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic obstructive pulmonary disease Respiratory

Interventions

This is an observational study in which indices of lung heterogeneity are measured in people who smoke but do not have diagnosed airways disease. A “Lung Heterogeneity test” is undert

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age 25-60 years 2. Current smokers with >10 pack years smoking history (Not applicable for the control group who are non-smokers)

Exclusion criteria

Exclusion criteria: 1. Current diagnosis of respiratory disease 2. Pregnancy 3. Significant cardiovascular disease e.g. heart failure

Design outcomes

Primary

Measure	Time frame
Lung heterogeneity indices: slnCL (standard deviation of alveolar compliance distribution across lung volume), sVD (standard deviation of deadspace distribution across lung volume), VD (total anatomical deadspace), and VD/FRC (ratio of total deadspace to functional residual capacity) measured using the novel technique at the Research Visit in chronic current smokers (tobacco smokers of >= 10 pack-years) with non-obstructive spirometry vs non-smoker healthy controls	—

Measure

Time frame

Lung heterogeneity indices: slnCL (standard deviation of alveolar compliance distribution across lung volume), sVD (standard deviation of deadspace distribution across lung volume), VD (total anatomical deadspace), and VD/FRC (ratio of total deadspace to functional residual capacity) measured using the novel technique at the Research Visit in chronic current smokers (tobacco smokers of >= 10 pack-years) with non-obstructive spirometry vs non-smoker healthy controls

—

Secondary

Measure	Time frame
1. Effect of participant pack years of smoking measured using smoking history data within questionnaires obtained at the Research Visit on the lung heterogeneity parameters. 2. Other potential markers of disease in smokers, e.g. markers of inflammation in blood (eosinophil count, CRP), exhaled nitric oxide and symptoms scores measured at the Research Visit and their correlation with the novel lung heterogeneity indices. 3. Other lung function measures: FEV1 % predicted , FEV1/FVC, FEF25-75%, measured with spirometry, and R5-R20, measured with impulse oscillometry at the Research Visit and their correlation with the novel heterogeneity indices.	—

Measure

Time frame

1. Effect of participant pack years of smoking measured using smoking history data within questionnaires obtained at the Research Visit on the lung heterogeneity parameters. 2. Other potential markers of disease in smokers, e.g. markers of inflammation in blood (eosinophil count, CRP), exhaled nitric oxide and symptoms scores measured at the Research Visit and their correlation with the novel lung heterogeneity indices. 3. Other lung function measures: FEV1 % predicted , FEV1/FVC, FEF25-75%, measured with spirometry, and R5-R20, measured with impulse oscillometry at the Research Visit and their correlation with the novel heterogeneity indices.

—

Countries

England, United Kingdom

Contacts

Public ContactNayia Petousi

nayia.petousi@ndm.ox.ac.uk+44 1865 857086

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026