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A randomised controlled trial of racemic epinephrine versus salbutamol for treatment of respiratory distress in bronchiolitis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN46561076
Enrollment
62
Registered
2005-04-20
Start date
1999-01-01
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bronchiolitis Respiratory Bronchiolitis

Interventions

Racemic epinephrine or salbutamol.

Sponsors

Lung Association of Nova Scotia (Canada)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Children less than two years of age with first episode wheezing.

Exclusion criteria

Exclusion criteria: Children were not eligible for enrollment if they: 1. Had a previous diagnosis of asthma 2. Were critically ill 3. Had chronic pulmonary or cardiac disease Other exclusion criteria included: 4. Allergy to sodium metabisulfite 5. Presence of tachycardia exceeding 200 beats per minute 6. Use of glucocorticoids 7. Sympathomimetic amines or monoamine oxidase inhibitor therapy

Design outcomes

Primary

MeasureTime frame
Wheezing and retractions measured by the Respiratory Distress Assessment Instrument each day during hospitalisation.

Secondary

MeasureTime frame
1. Length of stay 2. RSV antigen detection test 3. Feeding pattern 4. Adverse events 5. Parental report of feeding and respiratory status one week after discharge

Countries

Canada

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 15, 2026