Carotid artery stenosis Circulatory System
Conditions
Interventions
Participants with an indication for carotid endarterectomy (CEA) of the internal carotid artery will be included in the study.
The indication for surgery will be set according to the r
Sponsors
Klinicka bolnica Merkur
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Participants with an indication for carotid endarterectomy (CEA) of the internal carotid artery
Exclusion criteria
Exclusion criteria: Patients with a contraindication for MRI scan (presence of a ferromagnetic foreign body, claustrophobia)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measured at a single time point: 1. The characteristics and type of carotid atherosclerotic plaque measured by non-invasive radiological diagnostics (ultrasound/colour Doppler, MRI and/or MSCT scan) before surgery 2. Pathohistological characteristics and type of carotid atherosclerotic plaque measured using patohistological analysis after surgery 3. Expression of MMP-9 and COX-2 proteins in carotid atherosclerotic plaque after carotid endarterectomy measured using immunohistochemistry analysis after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured at a single time point: 1. Clinical and laboratory characteristics of patients measured by reviewing patient notes before and after surgery 2. Semiquantitative analysis of macrophages, smooth muscle cells and microvascular density in carotid atherosclerotic plaque and the histological type of bleeding within the plaque measured using patohistological analysis after surgery | — |
Countries
Croatia
Outcome results
None listed