Healthy subjects Not Applicable
Conditions
Interventions
Participants were allocated to one of the following groups:
1. Placebo
2. Omega-3 ethyl esters
3. Omega-3 free fatty acids
4. Omega-3 tr
Sponsors
Southampton University Hospitals NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Healthy 2. Aged 18 to 45 years 3. Body mass index 20 to 32 kg/m2 4. Not consuming fish oil or other oil supplements 5. Not eating more than one oily fish meal per week 6. Willing to adhere to the study protocol 7. Being able to provide written informed consent
Exclusion criteria
Exclusion criteria: 1. Aged 45 years 2. Body mass index 32 kg/m2 3. Being diabetic (type 1 or type 2) 4. Use of prescribed medicine to control inflammation 5. Chronic gastrointestinal problems (e.g. IBD, IBS, celiac disease, cancer) 6. Allergic to fish 7. Participation in another clinical trial 8. Use of fish oil or other oil supplements
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in EPA content of plasma phospholipids from study entry to week 12 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Change in EPA content of each of the other plasma lipid pools and of mononuclear cells and red blood cells from study entry to week 12 2. Change in DHA content of each of the plasma lipid pools and of mononuclear cells and red blood cells from study entry to week 12 3. Change over time in blood concentrations of inflammatory markers | — |
Countries
England, United Kingdom
Outcome results
None listed