Frailty Signs and Symptoms Frailty
Conditions
Interventions
The intervention is an eight-week program of multi-component resistance, aerobic, balance, and flexibility) exercise classes, combined with protein supplementation in the form of commercially availabl
Sponsors
Royal College of Surgeons in Ireland
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged =65 years 2. Clinical Frailty Scale (CFS) score of =5 as assessed by the multidisciplinary team of a geriatric medicine outpatient clinic
Exclusion criteria
Exclusion criteria: 1. Unable to mobilise without the assistance of another person 2. Severe cognitive or sensory impairment that would prevent participation in the intervention, even despite reasonable supports 2. Participation in any research that could impact on the outcome of this study 3. Documented milk-allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frailty assessed by Fried frailty criteria comprised of identification of weak grip strength, slow gait speed, excessive weight loss, exhaustion and reduced activity based on pre-determined thresholds at baseline, 8 and 16 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Falls risk as assessed by the Timed Up & Go (TUG) test at baseline, 8 and 16 weeks 2. Functional leg strength assessed by the 30-second sit-to-stand (30STS) test at baseline, 8 and 16 weeks 3. Frailty assessed by Electronic frailty Index (eFI) at baseline, 8 and 16 weeks 4. Body composition assessed by the Bio-electrical Impedance Analysis (BIA) using BodyStat Quadscan 4000 at baseline, 8 and 16 weeks 5. Arterial stiffness assessed by Carotid-femoral Pulse Wave Velocity (cfPWV) using Complior Analyse device & software at baseline, 8 and 16 weeks 6. Cognitive impairment assessed by Montreal Cognitive Assessment (MoCA) by face-to-face interview at baseline, 8 and 16 weeks 7. Depression assessed by the Geriatric Depression Scale Short Form (GDS-SF) by face-to-face interview at baseline, 8 and 16 weeks 8. Quality of life assessed by the CASP-19 quality of life scale by face-to-face interview at baseline, 8 and 16 weeks 9. Pain as assessed by the Pain Numerical Rating Scale (PNRS) by face-to-face interview at baseline, 8 and 16 weeks 10. Frailty assessed through biochemical markers of frailty in serum samples analysed using MagPix Luminex system (CRP, IL-6, IL-8, IL-10, TNF-alpha and IFN-gamma) and standalone ELISA (Cystatin-C) at baseline, 8 and 16 weeks | — |
Countries
Ireland
Contacts
Public ContactPádraig Bambrick
Outcome results
None listed