Chronic obstructive pulmonary disease (COPD) Respiratory Other chronic obstructive pulmonary disease
Conditions
Interventions
The study design will be a single blind randomised controlled study in which the patients will be randomised to one of two groups:
1. Pulmonary rehabilitation plus NMES
2. Pulmonary rehabilitation plu
Sponsors
Record Provided by the NHSTCT Register - 2007 Update - Department of Health
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnosis of COPD 2. Declining functional capacity (Medical Research Council [MRC] grade 3 and above) 3. On optimal pharmacological treatment 4. Clinical stable (no exacerbation within 4 weeks of initial assessment and not taking antibiotics/oral steroids for an acute infection) 5. Smokers will be included 6. Patients receiving long-term oxygen therapy (LTOT) will be included 7. Evidence of nutritional depletion - body weight less than 90% of ideal body weight (IBW) and/or fat-free mass (FFM) less than 69% IBW (males) and 67% IBW (females) 8. Evidence of peripheral muscle weakness (quadriceps force less than 80% predicted and/or hand grip strength less than 80% predicted)
Exclusion criteria
Exclusion criteria: 1. Unstable heart disease (and patients with pacemakers) 2. Untreated hypertension 3. Untreated hypothyroidism 4. Angina 5. Pregnancy 6. Arthritis (such that patient is unable to perform an exercise test and take part in an exercise training programme) or other mobility problems that will limit exercise capacity 7. Patients unable (or unwilling) to attend the hospital three times weekly for exercise training sessions 8. Patients unwilling to commit to lifestyle changes 9. Patients having an acute exacerbation of their disease within the previous 4 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in exercise tolerance assessed by the Incremental Shuttle Walking Test. This will be assessed by comparing the magnitude of the improvement in walking distance between patients randomised to receive pulmonary rehabilitation alone and those receiving pulmonary rehabilitation plus NMES. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Changes in peak oxygen uptake 2. Changes in endurance exercise performance 3. Changes in health status 4. Changes in muscle function 5. Changes in calf muscle blood flow capacity All these will be assessed in terms of firstly, whether there has been an overall improvement in the function in each group and secondly, whether there is a statistically significant difference in the magnitude of the improvement between patients receiving pulmonary rehabilitation alone and those receiving pulmonary rehabilitation plus NMES. | — |
Countries
United Kingdom
Outcome results
None listed