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The European CUP trial: a randomised trial in adults with poor risk relapsed follicular non-hodgkin's lymphoma

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN46399359
Enrollment
Unknown
Registered
2002-08-19
Start date
1992-04-30
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lymphoma (non-Hodgkin's) Cancer Lymphoma (non-Hodgkin's)

Interventions

Following registration all patients receive three, 3 week, cycles of chemotherapy with cyclophosphamide, adriamycin, vincristine and prednisone (CHOP). Patients who achieve a complete or partial res

Sponsors

Baxter AG (Switzerland)
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Relapsed follicular non-Hodgkin's lymphoma, after a first or subsequent remission, requiring therapy because of at least one of the following: 1.1. B symptoms 1.2. Rapidly progressive disease 1.3. Bone marrow failure 1.4. Life threatening organ failure 2. Aged 15 - 65 years 3. No central nervous system (CNS) involvement 4. No previous radiotherapy greater than 2000 cGy to the mediastinum or abdomen, precluding total body irradiation 5. No previous myeloablative therapy 6. No prior malignancies, except non-melanomatous skin cancer or cervical carcinoma stage I 7. Adequate cardiac, neurologic, liver and renal function 8. No evidence of histlogically proven transformation

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

MeasureTime frame
Not provided at time of registration—

Secondary

MeasureTime frame
Not provided at time of registration—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026