Clonorchis sinensis infection Infections and Infestations
Conditions
Interventions
Light infection (Eggs per gram of feces <1 000):
Group 1: albendazole with a dose of 400 mg, twice a day for 4 days
Group 2: praziquantel (25 mg/kg 3 times a day for 1 day)
Moderate and heavy infecti
Sponsors
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center For Tropical Disease Research)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients (18-70 years) infected with C. sinensis, as assessed by the presence of eggs in the stool 2. Signed written informed consent 3. Able and willing to be examined by a study physician at the beginning of the study and at the end of study follow-up survey (3-4 weeks post-treatment) 4. Able and willing to provide multiple stool samples at the beginning and end of study 5. Absence of major systemic illnesses, psychiatric and neurological disorders as assessed by the medical doctor, upon initial clinical assessment 6. No known or reported hypersensitivity to albendazole or praziquantel 7. No known or reported history of chronical illness as cancer, diabetes, chronic heart, liver or renal disease 8. For females, not pregnant, as assessed by a female nurse (interview and pregnancy test if need be), upon initial clinical assessment
Exclusion criteria
Exclusion criteria: 1. For females, pregnancy 2. Presence of any abnormal medical condition, judged by the study physician 3. History of acute or severe chronic disease 4. Known or reported hypersensitivity to albendazole or praziquantel 5. Known or reported psychiatric or neurological disorders 6. Use of any anthelminthic within the past month 7. Attending other clinical trials during the study 8. Absence of signed written informed consent sheet
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cure rates and egg reduction rates three weeks after treatment: For diagnosis two stool samples will be collected before and after treatment. From each stool sample three Kato-Katz thick smears will be examined. | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events due to specific treatment: Participants will be monitored 3 hours and 24 hours after treatment with a standard questionnaire for adverse events. | — |
Countries
China
Contacts
Public ContactMen-Bao Qian
Outcome results
None listed