Controlled Antenatal Thyroid Screening study

Randomised controlled trial of the effect of gestational thyroid hormone intervention therapy on childhood development

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN46178175

Enrollment

22000

Registered

2005-07-22

Start date

2002-06-01

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Childhood development Nutritional, Metabolic, Endocrine Hypothyroidism, unspecified

Interventions

Sera obtained from pregnant women before 16 weeks gestation. Sera randomised to 'screen' (T4 and Thyroid Stimulating Hormones [TSH] measured at time of randomisation) and 'control' (hormones measured

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: All pregnant women (aged 18 - 45 years) before 16 weeks gestation

Exclusion criteria

Exclusion criteria: 1. Twin pregnancy 2. Thyroid treatment (T4 or antithyroid drugs)

Design outcomes

Primary

Measure	Time frame
Intelligence Quotient (IQ) of children in screen and control groups.	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 27, 2026