Hypermetabolism, malnutrition and survival in cancer patients. Cancer
Conditions
Interventions
This study involved the measurement of resting energy expenditure by indirect calorimetry using with nose clip and mouthpiece system connected to an oxygen analyser (Fitmate ®, Cosmed, Brignais, Franc
Sponsors
Medical Oncology, Cochin Teaching Hospital, AP-HP, Paris Descartes University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Cancer outpatients and inpatients over 18 years. Patients were recruited as they benefit from a routinely evaluation before systemic treatment initiation. We included all cancer patients, any stage, evaluated before systemic treatment initiation including adjuvant chemotherapy.
Exclusion criteria
Exclusion criteria: 1. Patients who were not able to undergo indirect calorimetry (claustrophobia, oxygen therapy, flat nose bridge) 2. Patients who underwent anti-cancer therapy within the previous 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of weight loss in hypermetabolic patients to weight loss in normometabolic patients. 1. Weight loss is calculated as the percentage of weight lost from healthy condition to the date of recruitment: (recruitment weight-healthy weight)*100/healthy weight. 2. Metabolism is determined by measuring the resting energy expenditure (REE) by indirect calorimetry with nose clip and mouthpiece system connected to an oxygen analyser (Fitmate ®, Cosmed, Brignais, France). Measured REE is compared to calculated REE using revised Harris and Benedict equation: Hm is defined as having measured REE =110% of calculated REE, Nm 90 to 110% of calculated REE and hypometabolic patients <90%. All outcome data was measured on the day of indirect calorimetry . | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison between hypermetabolic and normometabolic patients for: 1. Patient general well-being and activities of daily life, assessed using the WHO performance status 2. C-reactive protein levels, measured using liquid turbidimetry 3. Albumin levels, measured using nephelemetry 4. Nutritional Risk index (NRI)=1.519× albumin +41.7×(current weight/usual weight), daily energy intake , energy balance (=daily energy intakes-Resting Energy expenditure), fat-free mass and overall survival 5. Energy intake, estimated for each patient by an experienced dietician using the 24-hour recall method 6. Fat free mass, measured by evaluation of skeletal muscle tissue cross-sectional area at the third lumbar vertebra on Computed tomography (when images available). Analyses were made with the ImageJ software v1.42q 7. Overall survival, defined as the time between inclusion and death All outcome data were collected on the day of indirect calorimetry except overall survival (median follow-up 15.5 month). | — |
Countries
France
Contacts
Public ContactClara;François Vazeille;Goldwasser
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Outcome results
None listed