Abdominal obesity Nutritional, Metabolic, Endocrine Obesity
Conditions
Interventions
Randomisation will take place once anthropometry is completed using an independent online computerized randomisation system by a member of the study team. Randomisation will be conducted at the level
Sponsors
Jagiellonian University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged between 18-65 years 2. Waist circumference >94 cm for men or >80 cm for women 3. BMI between 25-40 in kg/m2 4. Provided written informed consent
Exclusion criteria
Exclusion criteria: 1. Diabetes 2. Severe hyperlipidemia 3. Other endocrine and metabolic diseases 4. Chronic inflammatory states 5. Diseases of the digestive or respiratory systems 6. Chronic kidney disease 7. Cardiovascular disease 8. Alcohol addiction 9. Pregnancy or lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Waist circumference will be measured at baseline and 4 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Classic clinical biomarkers measured using Enzyme-Linked Immunosorbent Assay (ELISA) at baseline and 4 months 2. Metabolomics biomarkers measured using Nuclear Magnetic Resonance (NMR) and Liquid Chromatography-Mass Spectrometry (LC/MS) at baseline and 4 months 3. Food intake biomarkers measured using Liquid Chromatography-Ion Mobility Spectrometry-Quadrupole Time of Flight Mass Spectrometry (LC-IMS-QToF MS) at baseline and 4 months 4. Microbiome analysis in feaces using Next Generation Sequencing (NCS) at baseline and 4 months | — |
Countries
Poland
Outcome results
None listed