Dose-Responses to EXercise TRAining: a randomised controlled four year trial on the effects of regular physical exercise and diet on endothelial function, atherosclerosis and cognitive function

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN45977199

Enrollment

1500

Registered

2006-09-13

Start date

2003-01-15

Completion date

Unknown

Last updated

2016-11-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endothelial function, atherosclerosis Circulatory System Vascular diseases

Interventions

Participants are randomly allocated into: 1. Control group 2. Aerobic exercise 3. Resistance exercise 4. Diet 5. Combined aerobic exercise and diet 6. Combined resistance exercise and diet

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: A random population sample of the citizens in Kuopio, aged 55 to 74 years at the time of recruitment

Exclusion criteria

Exclusion criteria: Conditions that inhibit safe engagement in prescribed exercise training, malignant diseases and other conditions preventing co-operation, as judged by the research physicians.

Design outcomes

Primary

Measure	Time frame
Changes in: 1. Atherosclerosis 2. Endothelial function 3. Cognitive function	—

Secondary

Measure	Time frame
Changes in: 1. Inflammatory status 2. Metabolic risk factors 3. Cardiovascular risk factors	—

Countries

Finland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 27, 2026