Chronic venous or lymphatic disease Circulatory System
Conditions
Interventions
There will be 4 groups of participants, 12 in each group, making a total of 48:
Group 1: Patients with primary varicose veins
Group 2: Patients with the post-thromboti
Sponsors
Ealing Hospital NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Untreated varicose veins, previous deep venous thrombosis (DVT), lymphoedema or normal controls 2. Leg symptoms (unless a control subject) 3.1 Great saphenous reflux > 0.5 sec 3.2. Reflux > 1 sec and/or obstruction in deep veins on duplex 3.3. Confirmation of lymphoedema by lymphoscintigraphy 4. Agile and able to get on and off an examination couch 5. Ability to comprehend study demands
Exclusion criteria
Exclusion criteria: 1. Acute DVT within the last 3 months 2. Previous surgery/sclerotherapy for varicose veins 3. Venous ulceration over 2 cm in diameter 4. Gross pitting oedema of the ankle or calf 5. Pregnancy 6. Peripheral vascular disease [Ankle brachial pressure index (ABPI) < 0.9] 7. Cardiac failure 8. Breathlessness after mild exertion 9. Arthritis with significant impairment of mobility 10. Age less than 18 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantification of calf volume changes as a result of thigh-cuff inflations measured using air-plethysmography. The rate of change of calf volume and the amount of change will be measured at increasing thigh-cuff inflation pressures and after deflation. These outcomes will be measured during a single session lasting about 40 minutes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed