The CASPER-PLUS trial: collaborative care in screen positive elders with major depressive disorder

Conditions

Depression / mental well-being Mental and Behavioural Disorders Depressive episode

Bosanquet K, Adamson J, Atherton K, Bailey D, Baxter C, Beresford-Dent J, Birtwistle J, Chew-Graham C, Clare E, Delgadillo J, Ekers D, Foster D, Gabe R, Gascoyne S, Haley L, Hamilton J, Hargate R, Hewitt C, Holmes J, Keding A, Lewis H, McMillan D, Meer S, Mitchell N, Nutbrown S, Overend K, Parrott S, Pervin J, Richards DA, Spilsbury K, Torgerson D, Traviss-Turner G, Trépel D, Woodhouse R, Gilbody S.

2017-11-0132 citations

10.3310/hta21670

Revealing hidden depression in older people: a qualitative study within a randomised controlled trial.

Overend K, Bosanquet K, Bailey D, Foster D, Gascoyne S, Lewis H, Nutbrown S, Woodhouse R, Gilbody S, Chew-Graham C.

2015-10-1920 citations

10.1186/s12875-015-0362-2

CASPER plus (CollAborative care in Screen-Positive EldeRs with major depressive disorder): study protocol for a randomised controlled trial.

Overend K, Lewis H, Bailey D, Bosanquet K, Chew-Graham C, Ekers D, Gascoyne S, Hems D, Holmes J, Keding A, McMillan D, Meer S, Meredith J, Mitchell N, Nutbrown S, Parrott S, Parrott S, Richards D, Traviss G, Trépel D, Woodhouse R, Gilbody S.

2014-11-1913 citations

10.1186/1745-6215-15-451

Interventions

Eligible participants who have consented to be in the trial will be randomised into one of two intervention groups: 1. Collaborative Care (including Behavioural Activation) intervention with medicatio

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. CASPER participants will be identified by comprehensive screening strategies in primary care (replicating that which is incentivised in QOF-compliant case finding for those with CHD and diabetes). 2. Older people (aged 65 and above) 3. Who screen-positive for depression on the recommended QOF 2 question brief depression screen (sometimes referred to as the "Whooley" questions after their initial validation study ), but who on further assessment have Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) Major Depressive Disorder (MDD)

Exclusion criteria

Exclusion criteria: 1. Known alcohol dependency (as recorded on GP records) 2. Any known co-morbidity that would in the GP?s opinion make entry to the trial inadvisable (e.g. recent evidence of self harm, known current thoughts of self harm, significant cognitive impairment) 3. Other factors that would make an invitation to participate in the trial inappropriate (e.g. recent bereavement; terminal malignancy) 4. Known to be experiencing psychotic symptoms (as recorded on GP records)

Design outcomes

Primary

Measure	Time frame
Current primary outcome measure as of 17/11/2020: Primary outcome measure is depression severity measured by the PHQ9. The primary time point for the primary outcome measure is 4 months. PHQ9 also measured at 12 and 18 months to examine any sustained impact of the intervention _____ Previous primary outcome measure: Depression severity measured by the PHQ9 at 4,12 and 18 months	—

Secondary

Measure	Time frame
Current secondary outcome measures as of 17/11/2020: 1. Quality of Life measured by SF-12 at 4, 12 and 18 months 2. Anxiety measured by GAD-7 at 4, 12 and 18 months 3. Somatic symptoms measured using PHQ-15 at 4, 12 and 18 months 4. Resilience using the CD-RISC2 at 4, 12 and 18 months 5. Cost-effectiveness including the EQ-5D, prescribed medication and health and social care use _____ Previous secondary outcome measures: Presence/absence of depression diagnosis as ascertained by interview	—

Measure

Time frame

Current secondary outcome measures as of 17/11/2020: 1. Quality of Life measured by SF-12 at 4, 12 and 18 months 2. Anxiety measured by GAD-7 at 4, 12 and 18 months 3. Somatic symptoms measured using PHQ-15 at 4, 12 and 18 months 4. Resilience using the CD-RISC2 at 4, 12 and 18 months 5. Cost-effectiveness including the EQ-5D, prescribed medication and health and social care use _____ Previous secondary outcome measures: Presence/absence of depression diagnosis as ascertained by interview

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Countries

United Kingdom

Outcome results

None listed