A new treatment protocol reducing the risk of implantation failure and early pregnancy loss after transfer of embryos resulting from in vitro fertilisation

Efficient treatment of luteal phase deficiency in HCG-triggered IVF cycles by prolonged administration of GnRH agonist after embryo transfer

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN45835041

Enrollment

Registered

2018-07-05

Start date

2016-09-01

Completion date

Unknown

Last updated

2018-07-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Luteal phase insufficiency in assisted reproduction Pregnancy and Childbirth Luteal phase insufficiency

Interventions

In women who failed to get pregnant and had an abnormally low serum progesterone concentration after uterine transfer of embryos resulting from in vitro fertilisation, the protocol of the subsequent a

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Women 2. Aged between 28 and 39 years, 3. Failed to become pregnant 4. Had low luteal-phase progesterone levels in a previous in vitro fertilization attempt

Exclusion criteria

Exclusion criteria: 1. Age of >40 years 2. Andrological gynecological and systemic pathologies unrelated to the corpus luteum function: 2.1. Azoospermia 2.2. Necrozoospermia 2.3. Uterine polyps and fibroids 2.4. Polycystic ovary syndrome 2.5. Endometriosis 2.6. Cushing syndrome 2.7. Diabetes 2.8. Hypothyreosis and hyperthyreosis 2.9. Body mass index >29

Design outcomes

Primary

Measure	Time frame
Clinical pregnancy rate (number of pregnancies divided by the number of embryo transfer procedures) is measured from medical records 3 months after embryo transfer	—

Secondary

Measure	Time frame
1. Implantation rate (number of gestational sacs containing a living embryo implanted in the uterus divided by the number of embryos transferred) is measured from medical records 6 weeks after embryo transfer 2. Serum progesterone concentration is measured using immunoassay at the 7th and 14th day after embryo transfer 3. Total dose of progesterone administered is measured from medical records at the 14th day after embryo transfer	—

Measure

Time frame

1. Implantation rate (number of gestational sacs containing a living embryo implanted in the uterus divided by the number of embryos transferred) is measured from medical records 6 weeks after embryo transfer 2. Serum progesterone concentration is measured using immunoassay at the 7th and 14th day after embryo transfer 3. Total dose of progesterone administered is measured from medical records at the 14th day after embryo transfer

—

Countries

Spain

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026