The association between various diagnostic measurements and lung function

Pulmonary function test association with clinical, laboratory, histological and radiological characteristics – a prospective study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN45778591

Enrollment

20000

Registered

2020-06-08

Start date

2019-04-01

Completion date

Unknown

Last updated

2025-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory diseases Respiratory

Interventions

Non-invasive measurements specific to the project and performed in all participants, include: N2 washout (single and multiple breath): Single breath - the measurements are carried out with the patient

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Older than 18 years 2. Capable to perform an acceptable spirometry 3. Able to answer questionnaires 4. With or without respiratory symptoms 5. With or without diagnosed respiratory disease

Exclusion criteria

Exclusion criteria: Does not meet inclusion criteria

Design outcomes

Primary

Measure	Time frame
Measured at a single time point: 1. LCI measured using the multiple-breath nitrogen washout (N2-MBW) 2. Phase III slope (SIII) measured using the single-breath nitrogen washout (N2-SBW) and single-breath double tracer gas washout (DTG-SBW)	—

Secondary

Measure	Time frame
Measured at a single time point: 1. Scond, Sacin, area under the curve of DTG-SBW measured using the multiple-breath nitrogen washout (N2-MBW) 2. Bronchoprovocation test outcomes such as PD20 and PD40 3. Volatile organic compounds in the breath measured using Aeonose 4. Sleepiz One measurements (breathing, heart rate, movement during sleep) 5. Known clinical, laboratory, histological and radiological characteristics measured using patient records	—

Measure

Time frame

Measured at a single time point: 1. Scond, Sacin, area under the curve of DTG-SBW measured using the multiple-breath nitrogen washout (N2-MBW) 2. Bronchoprovocation test outcomes such as PD20 and PD40 3. Volatile organic compounds in the breath measured using Aeonose 4. Sleepiz One measurements (breathing, heart rate, movement during sleep) 5. Known clinical, laboratory, histological and radiological characteristics measured using patient records

—

Countries

Switzerland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 5, 2026