Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomised trial

Conditions

Major depression Mental and Behavioural Disorders Depression

Hamed Delam, Zahra Keshtkaran, Nasrin Shokrpour, Ahmadreza Eidi, Mohammad-Rafi Bazrafshan

BMC Complementary Medicine and Therapies2023-06-0112 citations

A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression.

Araj-Khodaei M, Noorbala AA, Yarani R, Emadi F, Emaratkar E, Faghihzadeh S, Parsian Z, Alijaniha F, Kamalinejad M, Naseri M.

2020-07-0335 citations

10.1186/s12906-020-03003-5

A naturalistic study of herbal medicine for self-reported depression and/or anxiety a protocol

David Casteleijn, Amie Steel, Diana Bowman, Romy Lauche, Jon Wardle

Integrative Medicine Research2019-04-2010 citations

10.1016/j.imr.2019.04.007

The ocular hypotensive effect of saffron extract in primary open angle glaucoma: a pilot study.

Jabbarpoor Bonyadi MH, Yazdani S, Saadat S.

2014-10-1543 citations

10.1186/1472-6882-14-399

Interventions

In this double-blind, single-centre trial, patients were randomly assigned to receive capsule of saffron 30 mg/day (10 mg three times a day [TDS]) (Group 1) and capsule of imipramine 100 mg/day (33.3

Eligibility

Inclusion criteria

Inclusion criteria: 1. Thirty adult outpatients who met the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM IV) for major depression based on the structured clinical interview for DSM IV participated in the trial 2. Patients have a baseline Hamilton Rating Scale for Depression score of at least 18

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

Measure	Time frame
Not provided at time of registration	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

Iran

Outcome results

None listed