Specialty: Primary Care, Primary sub-specialty: Ageing Signs and Symptoms Mobility-related disability
Conditions
Interventions
Participants are randomly allocated to one of two groups.
Intervention group: Participants will receive a standardised 12-month programme designed for delivery in leisure/community centres and fitnes
Sponsors
University of Bath
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Retired men and women aged 65 or older 2. Plan to reside in the target area (Bath/Bristol, Devon, Birmingham) for at least 24 months 3. Score 48 (inclusive) on the Short Physical Performance Battery (SPPB)
Exclusion criteria
Exclusion criteria: 1. A documented or patient reported medical condition that would preclude participation, including: 1.1. Arthritis so severe it would prevent participation in physical activity 1.2. Parkinson’s disease 1.3. Dementia 1.4. Lung disease requiring use of corticosteroids or supplemental oxygen 1.5. Severe kidney disease that requires dialysis 1.6. Severe heart disease that would prevent participation in physical activity (for example chest pain when walking one or two hundred yards or up a flight of stairs) 1.7. An implanted cardiac defibrillator, a cardiac arrest which required resuscitation 1.8. Severe uncontrolled psychiatric illness 1.9. Currently receiving radiation therapy or chemotherapy treatment for cancer 1.10. Awaiting knee or hip surgery 1.11. Major heart surgery (including valve replacement or bypass surgery) or spinal surgery in the last six months 1.12. Any other clinical condition that their GP or clinician considers would make them unsuitable for participation in a physical activity rehabilitation programme to prevent decline of lower limb functioning 2. Self-reported inability to walk across a room or the need for a walker or the help of another person 3. Existing major mobility limitation. 4. Being unable to complete the 4m walk component of SPPB 5. Current involvement in other regular (at least weekly) exercise programmes that aim to build lower limb capacity or fitness (e.g. walking programmes) 6. Living in residential or nursing care 7. Another member of the household participating in REACT
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional performance is measured using the Short Physical Performance Battery (SPPB) score at baseline, 6, 12 and 24 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Minutes of moderate intensity physical activity as measured by wrist-worn accelerometers at baseline, 6, 12 and 24 months 2. Sedentary time and breaks in sedentary time per day assessed by wrist-worn accelerometers at baseline, 6, 12 and 24 months 3. Self-reported physical activity (PASE questionnaire) at baseline, 6, 12 and 24 months 4. Hand grip strength of the dominant hand using a digital dynamometer at baseline, 6, 12 and 24 months 5. Ageing Well Profile Social scale (6 items) at baseline, 6, 12 and 24 months 6. Activities of daily living (ADL) (EQ-5D, SF-36, MAT-sf) at baseline, 6, 12 and 24 months 7. The UK Biobank Healthy Minds Questionnaire (memory, attention and executive function) at baseline, 6, 12 and 24 months 8. The incremental cost-effectiveness of the REACT intervention (EQ-5D, SF-36) at baseline, 6, 12 and 24 months 9. Pain (Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at baseline, 6, 12 and 24 months 10. Sleep Condition Indicator at baseline, 6, 12 and 24 months 11. Medical history at baseline, 6, 12 and 24 months 11. Falls Inventory at baseline, 6, 12 and 24 months 12. Health and Social Service Usage at baseline, 6, 12 and 24 months 13. Process Evaluation at 24 months 14. fMRI imaging sub-study at baseline, 6, 12 and 24 months 15. Rate of brain atrophy and decline in cognitive function (fMRI scan) at baseline, 6, 12 and 24 months | — |
Countries
England, United Kingdom
Contacts
Public ContactAfroditi Stathi
Outcome results
None listed