Dilution of ropivacaine by saline can decrease its dose requirement in spinal anesthesia for cesarean section

Dilution of ropivacaine by saline can decrease its dose requirement in spinal anesthesia for cesarean section: a randomized blinded controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN45576750

Enrollment

Registered

2011-12-09

Start date

2011-07-31

Completion date

Unknown

Last updated

2017-06-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elective cesarean delivery Pregnancy and Childbirth Elective cesarean delivery

Interventions

The patients were randomly allocated to 2 groups to receive combined spinal epidural anesthesia for cesarean section. Group RS received intrathecal isobaric 1% ropivacaine (Naropin, AstraZeneca, Chi

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. American Society of Anesthesiologists (ASA) physical status I to II 2. Undergoing elective cesarean delivery 3. No contraindications to subarachnoid anesthesia

Exclusion criteria

Exclusion criteria: 1. Allergic to local anesthetics 2. Emergent cesarean deliveries 3. Body mass index (BMI) 30 4. Hypertensive disorders 5. Peripartum hemorrhagic conditions 6. Neurologic, cardiac or hematologic diseases 7. Diabetes 8. Eclampsia 9. Fetal distress, or known fetal anomalies

Design outcomes

Primary

Measure	Time frame
1. Effective Dose 50 (ED50) of ropivacaine for intrathecal administration 2. The rate of adequate anesthesia	—

Secondary

Measure	Time frame
1. Heart rate 2. Systolic, diastolic, and mean arterial blood pressure 3. Hemoglobin oxygen saturation	—

Countries

China

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026