Post-operative atrial fibrillation Circulatory System Atrial fibrillation and flutter
Conditions
Interventions
Oral administration of:
1. Omega-3 polyunsaturated fatty acids: 1 g every 12 hours, beginning 7 days before surgery, until hospital discharge
2. Vitamin C: 500 mg every 12 hours, beginning 2 days befo
Sponsors
Fondo de Desarrollo Científico y Tecnológico (Chile)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged between 30 - 80 years, either sex 2. Scheduled for elective coronary artery bypass graft, valve surgery, or mixed 3. In sinus rhythm
Exclusion criteria
Exclusion criteria: 1. Previous heart surgery 2. Pre-operative documented history of chronic or paroxysmal AF 3. Comorbidities such as congenital or cardiac re-operation 4. Advanced hepatic disease (cirrhosis) 5. Chronic renal failure (serum creatinine greater than 2.0 mg/dL)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ocurrence of post-operative atrial fibrillation. Basal electrocardiogram for patients in sinus rhythm and electrocardiographic monitoring will be performed throughout the hospitalisation period, in order to detect the occurrence of atrial fibrillation. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Biochemical markers of oxidative stress, performed on blood samples withdrawn: 7 and 2 days before surgery, the day of surgery, 8 hours and 4 days after surgery 2. Atrial tissue will be obtained during surgery to be analysed | — |
Countries
Chile
Outcome results
None listed