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Misoprostol in the management of retained placenta - a safe alternative for manual removal? A randomised controlled trial

Misoprostol in the management of retained placenta - a safe alternative for manual removal? A randomised controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN45330307
Enrollment
100
Registered
2007-08-23
Start date
2007-08-01
Completion date
Unknown
Last updated
2021-10-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Retained placenta Pregnancy and Childbirth Complications of labour and delivery

Interventions

All women with retained placenta after vaginal birth will be included in our study. In the case of a retained placenta, administration of either 800 mcg of misoprostol or placebo 60 minutes after birt

Sponsors

Leiden University Medical Centre (LUMC) (The Netherlands)
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1. All women with at least 25 completed pregnancy weeks and retained placenta 2. At least 18 years of age 3. Master the Dutch language in word and script

Exclusion criteria

Exclusion criteria: 1. Excessive blood loss (greater than 1000 ml) within 60 minutes after the delivery of the newborn 2. Allergy for misoprostol or one of its components

Design outcomes

Primary

MeasureTime frame
1. Number of spontaneous delivered placentas 2. Number of manual removals and amount of blood loss

Secondary

MeasureTime frame
1. Interval between delivery of the baby and administration of misoprostol 2. Interval between administration of misoprostol and delivery of the placenta 3. Placenta captiva

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026