Genetic polymorphisms in a beta-carotene metabolising enzyme

Do genetic polymorphisms in a beta-carotene metabolising key enzyme influence dietary vitamin A requirements?

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN45245618

Enrollment

200

Registered

2010-05-12

Start date

2009-09-01

Completion date

Unknown

Last updated

2019-11-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Generic Health Relevance and Cross Cutting Themes

Interventions

The intervention will last 14 days. However, first contact with the study participants will be 2 months prior to the start of the intervention to explain the study. A capsule containing 2 mg dose of b

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18 - 45 years 2. Generally fit and healthy adults 3. Males and females

Exclusion criteria

Exclusion criteria: 1. Smokers 2. Pregnant females 3. Diabetics 4. Liver disease 5. Gastrointestinal disorders

Design outcomes

Primary

Measure	Time frame
Blood concentrations of administered beta-carotene/retinyl acetate, and derived metabolites. Primary outcome measures will be taken at 0, 2, 4, 6, 8, 12 hours on day 1. Then at days 2, 3, 7, and 14.	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026