Angle-closure glaucoma Eye Diseases Glaucoma
Conditions
Interventions
Current intervention as of 17/01/2022:
The right and left eyes of each participant will be randomly allocated to the intervention treatment or no treatment (control).
Intervention treatment: Laser p
Sponsors
University College London (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Anatomically narrow drainage angles in the anterior segment of the eye 2. No evidence of primary angle-closure (high pressure or peripheral anterior synechiae) 3. Aged greater than or equal to 50 years
Exclusion criteria
Exclusion criteria: 1. Inability or unwillingness to give informed consent 2. Raised intraocular pressure, peripheral anterior synechiae or glaucomatous optic neuropathy 3. Previous intraocular surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The following will be assessed on each of the scheduled follow-up (6, 18, 30 and 42 months): 1. Raised intraocular pressure (either with or without symptoms). Intraocular pressure greater than 24 mmHg verified on two consecutive measurements on separate days. These patients will be further identified as having open, partially-closed or completely closed angles on dark room gonioscopy and anterior segment optical coherence tomography (AS-OCT). 2. Peripheral anterior synechiae 3. Glaucomatous optic neuropathy If participants are felt to have met a failure criterion, they are re-assessed (by examination with one of the senior investigators) within the next 2 weeks to confirm. The failure will then be classified as having occurred at 6, 18, 30 or 42 months (end of the study). Added 20/09/2016: Outcomes will also be assessed at 54 and 72 months. If participants are felt to have met a failure criterion, they are re-assessed (by examination with one of the senior investigators) within the next 2 weeks to confirm. The failure will then be classified as having occurred at 54 or 72 months (end of the study). | — |
Secondary
| Measure | Time frame |
|---|---|
| The following will be assessed on each of the scheduled follow-up (6, 18, 30 and 42 months): 1. Specular microscopy measures of corneal endothelial cell loss 2. Formation of lens opacity 3. Anterior segment optical coherence tomography measures (qualitative and quantitative) of ocular anterior segment anatomy 4. Digital iris photograph measures of iris 5. Ultrasound biomicroscopy measurements of ocular anterior segment anatomy If participants are felt to have met a failure criterion, we will re-assess (by examination with one of the senior investigators) within the next 2 weeks to confirm. The failure will then be classified as having occurred at 6, 18, 30 or 42 months (end of the study). Added 20/09/2016: Outcomes will also be assessed at 54 and 72 months. If participants are felt to have met a failure criterion, they are re-assessed (by examination with one of the senior investigators) within the next 2 weeks to confirm. The failure will then be classified as having occurred at 54 or 72 months (end of the study). | — |
Countries
Australia, China, England, United Kingdom, United States of America
Outcome results
None listed