Liver cancer Cancer Liver metastases from colorectal cancer.
Conditions
Interventions
Patients with liver metastases from colorectal cancer scheduled for a potentially curative normal or extended right hemihepactomy.
The study will be performed as a prospective randomi
Sponsors
University of Heidelberg Medical School (Germany)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Hospitalised patients of the Department of Surgery, University of Heidelberg or of the Hepatobiliary Division, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, aged greater than 18 years (no upper age limit) 2. Are considered for a potentially curative (R0) right hepatectomy (removal of segments 5,6,7,8), extended right hepatectomy (removal of segments 5,6,7,8, part of segment 4) or right trisegmentectomy (removal of segments 4,5,6,7,8) for colorectal liver metastases There will be 150 patients (75 each group) accrued in this study (excluding patients who underwent R1 resection and/or with an intraoperative blood loss of greater than or equal to 2000 cc).
Exclusion criteria
Exclusion criteria: Patients with positive extrahepatic spread (including positive lymph nodes) routinely do not undergo liver resection, these patients will therefore be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the anterior approach to the conventional technique of hepatic resection for colorectal metastases with respect to the incidence of intraoperative haematogenous tumour cell dissemination. We hypothesise that intraoperative haematogenous tumour cell dissemination could be reduced or prevented by using the anterior approach technique in resection of colorectal liver metastases. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Survival of the patients (overall and disease-free survival) 2. Blood loss 3. Duration time of resection 4. Transfusion requirements 5. Complication rates Assessed between the two different liver resection techniques. Furthermore the prognostic relevance of tumor cell detection in blood and bone marrow and the comparison of tumor cell detection by different detection methods will be analysed. | — |
Countries
Germany, United States of America
Outcome results
None listed