Cognitive function after sevoflurane- versus propofol-based anaesthesia for on-pump cardiac surgery

Cognitive function after sevoflurane- versus propofol-based anaesthesia for on-pump cardiac surgery: a randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN44821042

Enrollment

128

Registered

2010-03-15

Start date

2006-09-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac surgery, cognitive dysfunction Surgery Cardiac surgery

Interventions

Anaesthesia protocol 1: intravenous group (PROP): Induction: etomidate 0.2 - 0.3 mg/kg, sufentanil 1 µg/kg, pancuronium 0.07 - 0.1 mg/kg Maintenance: remifentanil 0.2 - 0.25 µg/kg/min, propofol 3 - 5

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged between 18 and 85 years, either sex 2. Elective or urgent cardiac surgery with cardiopulmonary bypass 3. American Society of Anaesthesiologists (ASA) grade I to IV

Exclusion criteria

Exclusion criteria: 1. Overt neurological diseases or dementia 2. Significant stenosis of the carotid arteries 3. Pregnancy 4. Disposition for malignant hyperthermia 5. Use of monoamine oxidase-inhibitors 6. Insufficient knowledge of the German language 7. Emergency indication

Design outcomes

Secondary

Measure	Time frame
1. Markers of myocardial, cerebral and renal damage (creatine kinase [CK]/creatine kinase myocardial bands [CK-MB], troponin, high sensitivity troponin [hsTroponin], N-terminal prohormone brain natriuretic peptide [NT-proBNP], neurone specific enolase [NSE], beta-subunit of S100 protein [S100beta], neutrophil gelatinase-associated lipocalin [NGAL], cystatin C [CysC], creatinine), measured 2, 4 and 6 days after surgery 2. Clinical outcome concerning brain, kidney and heart, recorded 6 days after surgery	—

Measure

Time frame

1. Markers of myocardial, cerebral and renal damage (creatine kinase [CK]/creatine kinase myocardial bands [CK-MB], troponin, high sensitivity troponin [hsTroponin], N-terminal prohormone brain natriuretic peptide [NT-proBNP], neurone specific enolase [NSE], beta-subunit of S100 protein [S100beta], neutrophil gelatinase-associated lipocalin [NGAL], cystatin C [CysC], creatinine), measured 2, 4 and 6 days after surgery 2. Clinical outcome concerning brain, kidney and heart, recorded 6 days after surgery

—

Primary

Measure	Time frame
Cognitive function measured with the abbreviated mental-test (AMT), stroop-test, trail-making-test (TMT), word-lists (WL), and mood-assessment-tests on day 2, 4 and 6 after cardiac surgery	—

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026