A population based randomised controlled trial of Helicobacter pylori eradication: impact on dyspepsia, quality of life and health

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN44816925

Enrollment

1550

Registered

2006-08-29

Start date

1996-05-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dyspepsia Digestive System Dyspepsia

Interventions

Subjects were screened for H. pylori. Those who were positive were randomised between active eradication therapy or a placebo. Subjects were not randomised if they were found to be uninfected with H.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 20 to 59 years, male and female 2. Able to give written informed consent

Exclusion criteria

Exclusion criteria: Any persons with the following conditions: pregnancy, breast feeding, severe renal impairment, adverse reaction to macrolide antibiotics, concurrent medication with wafarin, theophyllin, digoxin, terfendine, carbemazepine, ergot derivatives, bismuth compounds, acute porphyria.

Design outcomes

Primary

Measure	Time frame
Dyspepsia resolution at two years after randomisation.	—

Secondary

Measure	Time frame
1. Reduction in health service utilisation 2. Quality of life	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 5, 2026