Bladder or cervix cancer Cancer 1. Malignant neoplasm of bladder 2. Maligant neoplasm of cervix uteri
Conditions
Interventions
Cranberry juice or placebo
Sponsors
Greater Glasgow NHS Board, North Glasgow Division (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with cervical cancer about to start standard chemoradiation (weekly cisplatin chemotherapy plus radiation therapy as below) or radiation therapy (4300-4500 cGy over 20 fractions +/-selectron radiotherapy) 2. OR patients with bladder cancer about to commence standard radical radiotherapy (5000-5240 cGy over 20 fractions). 3. Age = 18 years. 4. ECOG performance status = 2. 5. Written informed consent and the ability to comply with the requirements of the study.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women are excluded. Female patients of child-bearing potential are eligible provided they have a negative urine pregnancy test prior to enrolment and agree to use approved contraceptive precautions during the trial and for 6 months afterwards. 2. Patients with irritable bowel syndrome (they may experience episodes of diarrhoea as a side effect of drinking cranberry juice). 3. Patients who are diabetic (due to the high sugar content of the juice). 4. Patients who have rheumatoid arthritis (the acidic juices may exacerbate joint pain). 5. Patients with urinary symptoms or urinary tract infections at baseline. 6. Patients receiving antispasmodics or antibiotics for urinary symptoms. 7. Patients with an indwelling urinary catheter.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Increase in Common Toxicity Criteria (CTC) grade of urinary tract symptoms OR development of urinary tract infection | — |
Secondary
| Measure | Time frame |
|---|---|
| Other CTC toxicities | — |
Countries
United Kingdom
Outcome results
None listed