Breath analysis in intensive care

BReath Analysis in intensive care: proof of concept for non-invasive diagnosis of Ventilator associated pneumonia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN44583186

Enrollment

120

Registered

2015-07-02

Start date

2015-07-01

Completion date

Unknown

Last updated

2021-05-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator-associated pneumonia (VAP) Respiratory

Interventions

Included patients will have been intubated and mechanically ventilated for at least 48 hours (based on the definition of VAP) and clinically suspected of having VAP. Exhaled air samples will be taken

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria 1. 18 years and older 2. Intubated and mechanically ventilated for >48 hours 3. Suspected for ventilator associated pneumonia (VAP) Definition of suspected VAP Criteria for clinically suspected VAP are fulfilled if a patient has been intubated and mechanically ventilated for at least 48 hours and has new or worsening alveolar infiltrates on chest X-ray and has two or more from 1. Temperature >38°C or 11x109 or <4x109 per litre of blood 3. Purulent tracheal secretions

Exclusion criteria

Exclusion criteria: 1. Patients receiving end of life care 2. Patients where there is clinical suspicion of highly infectious disease (patients in strict isolation such as Middle East Respiratory Syndrome, Ebola or resistant tuberculosis) 3. Patients showing features considered to predict poor tolerance of BAL: 3.1. PaO2 0.7 3.2. Positive end-expiratory pressure >15 cmH2O 3.3. Peak airway pressure >35 cmH2O 3.4. Heart rate >140 bpm 3.5. Mean arterial pressure 3) 3.7. Poorly controlled intracranial pressure (>20mmHg)

Design outcomes

Primary

Measure	Time frame
Providing proof of concept supporting the use of a novel minimally-invasive breath sampler to enhance the diagnosis of ventilator-associated pneumonia (VAP) in patients in intensive care.	—

Secondary

Measure	Time frame
1. The development of a bespoke minimally-invasive breath sampling methodology for critically ill ventilated patients on a mechanical ventilator 2. Precise identification of the breath biomarkers / VOCs responsible for discriminating VAP in critical ill patients	—

Countries

United Kingdom

Contacts

Public ContactPouline van Oort

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026