Randomised controlled trial of carbamazepine assisted detoxification in patients with benzodiazepine dependence

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN44535130

Enrollment

Registered

2005-09-30

Start date

2004-09-21

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mental and Behavioural Disorders: Addiction Mental and Behavioural Disorders Addiction

Interventions

1. Carbamazepine assisted benzodiazepine detox for 2 weeks 2. Traditional gradual withdrawal of diazepam Observers will be blinded from allocation of groups. Analysis of Variance (ANOVA) will be used

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients (18-65 years) who are admitted to Wentworth House or Kenyon House in-patient units, and are using daily doses of benzodiazepine for at least 3 months.

Exclusion criteria

Exclusion criteria: 1. Significant psychiatric disorders (by ICD 10) 2. History of or current liver failure 3. Current Alanine Transaminase ( ALT) > or equal 150 IU/l in serum LFT 4. Current suicidal ideation 5. Patients who are already on Carbamazepine before referral for In Patient treatment.

Design outcomes

Primary

Measure	Time frame
1. Benzodiazepine withdrawal symptom questionnaire (30 items) 2. Hamilton Depression Rating Scale (17 items) HAM-D) 3. Hamilton Anxiety Rating Scale (HAM-A) 4. Abstinence rates from benzodiazepines Patients will be assessed at 3 points: 1. Baseline 2. 1 week after starting the detoxification 3. 2 weeks (end of detoxification) Follow-up interview or phone call will be made 4 weeks after discharge asking if patient are abstinent from benzodiazepines.	—

Measure

Time frame

1. Benzodiazepine withdrawal symptom questionnaire (30 items) 2. Hamilton Depression Rating Scale (17 items) HAM-D) 3. Hamilton Anxiety Rating Scale (HAM-A) 4. Abstinence rates from benzodiazepines Patients will be assessed at 3 points: 1. Baseline 2. 1 week after starting the detoxification 3. 2 weeks (end of detoxification) Follow-up interview or phone call will be made 4 weeks after discharge asking if patient are abstinent from benzodiazepines.

—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026