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Pulp regeneration for permanent mature teeth by application of normal scaffolds

A comparative clinical study between the application of three types of normal scaffolds in pulp regeneration for permanent mature teeth with periapical lesions

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN44531236
Enrollment
30
Registered
2024-07-08
Start date
2020-06-25
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Necrotic single-rooted permanent straight teeth with mature roots Oral Health

Interventions

Thirty necrotic single-rooted permanent teeth with mature roots from healthy people aged between 15-45 years old will be randomly divided into three groups using https://www.random.org: Group A (contr

Sponsors

Damascus University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Aged between 15-45 years old with necrotic single-rooted permanent straight teeth with mature root 2. Radiographical presence of periapical lesions less than 10 mm in diameter 3. Healthy and free of any systemic diseases 4. Patients with a negative response to the allergic patch test (triple antibiotic paste) were included in the study 5. Willingness to cooperate and commit to work sessions and follow-ups

Exclusion criteria

Exclusion criteria: 1. Teeth that are grossly decayed or fractured which cannot be isolated with the rubber dam and require post and core as final restorations 2. Teeth with previous root canal treatment 3. Teeth with root fracture or with external and internal resorption and teeth with developmental anomalies 4. Patients with generalized chronic periodontitis and the presence of draining sinus 5. Patients with calcified canals, canals with apparent curvature 6. Patients who were allergic to any drugs 7. Patients with systemic disease 8. Pregnancy 9. Patients with a history of major surgeries like cardiac, kidney transplantation, hemodialysis

Design outcomes

Primary

MeasureTime frame
The condition of the periapical lesion will be measured clinically (spontaneous or palpable pain, soft tissue swelling, or sinus tract) using a vitality test and using radiographical scoring at 1, 3, 6, and 12-month intervals

Secondary

MeasureTime frame
1. Patient demographic information (age in years and sex) recorded during the patient examination at a baseline visit 2. Apex diameter (in mm) and working length (in mm) measured using a 35# k file during the preparation phase

Countries

Syria

Contacts

Public ContactAliaa;Aliaa Alshahhoud;Alshahhoud

;

alia.alshahhoud@damascusuniversity.edu.sy;aliaalshahhoud@gmail.com+963(0)955473352;+963(0)955473352

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026