Ketamine to reduce postoperative pain in back surgery

Administration of S-Ketamine during spinal surgery to reduce postoperative pain

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN44502774

Enrollment

192

Registered

2012-10-10

Start date

2013-01-01

Completion date

Unknown

Last updated

2021-02-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Optimal dose of S-ketamine to reduce the need of opioid medication in the postoperative period Surgery

Interventions

The study will involve 192 adult patients undergoing elective posterior lumbar fusion surgery. The patienst will be randomized into three groups: 64 patients will be given placebo (NaCl 0,9%), 64 pat

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adult patients (18 years and older) undergoing elective posterior lumbar fusion surgery

Exclusion criteria

Exclusion criteria: 1. BMI>35 2. Unstable ischaemic cardiac disease 3. Increased intracranial pressure 4. Increased intraocular pressure 5. Gravidity 6. Lactation 7. Hypersensivity or allergy to ketamine, oxycodone, propofol or remifentanil 8. Severe psychiatric disease 9. Unwillingness or unability to ude PCA-device 10. Inability to use NRS-pain scale

Design outcomes

Primary

Measure	Time frame
Evaluate the effect of different dosages of S-ketamine in the intraoperative period on the need of postoperative opioid medication	—

Secondary

Measure	Time frame
Evaluate the postoperative confusion, pain and depression in the different study groups	—

Countries

Finland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026