Effects of personalized exercise training on physical activity, health-related fitness, sleep quality, and quality of life among middle-aged and older adults with multiple health problems

The effect of aerobic exercise training on physical activity, health-related fitness, sleep quality, and quality of life among middle-aged and older adults with multimorbidity

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN44497123

Enrollment

Registered

2020-10-29

Start date

2016-11-09

Completion date

Unknown

Last updated

2022-03-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multimorbidity (more than two of the following: hypertension, hyperlipidemia, diabetes, stroke, cancer, heart disease, kidney disease, asthma, chronic obstructive pulmonary disease, osteoporosis, degenerative arthritis, gout, depression, schizophrenia, and bipolar disorder) Not Applicable

Interventions

A randomized controlled trial with three groups was created. All eligible middle-aged and older adults with multimorbidity were randomized by a research assistant to one of three groups:

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Over 40 years old with multimorbidity 2. No cognitive impairment (MMSE > 24) 3. Able to communicate in Mandarin 4. Provided informed consent 5. Current physical activity amount does not meet the WHO recommendations (<150 minutes of moderate-intensity physical activity/week or <75 minutes of vigorous-intensity physical activity/week).

Exclusion criteria

Exclusion criteria: 1. Aerobic exercise training contraindications according to the updated ACSM recommendations for exercise preparticipation health screening as demonstrated by a rehabilitation/sports medicine physician 2. Unable to tolerate moderate to vigorous aerobic exercise training due to impaired neurogenic/musculoskeletal conditions 3. Unable to cooperate with aerobic exercise training 4. Unable to walk without assistance 5. Have been judged to be unsuitable for participation in this study by a rehabilitation/sports medicine physician for other reasons

Design outcomes

Primary

Measure	Time frame
Measured at baseline and after 12 weeks: 1. Demographic data measured by self report 2. Self-perceived health status measured using the Self-perceived health status scale (Chinese version) 3. Activity measured using the International Physical Activity Questionnaire (IPAQ)-Chinese version short form 4. Objective measurements of health-related physical fitness parameters were performed by a well-trained research assistant: 4.1. Resting heart rate and blood pressure 4.2. Body mass index (BMI) (kg/m²) 4.3. Upper limb grip strength 4.4. Muscular endurance measured using the 30-second chair stand test 4.5. Flexibility measured using the chair sit-and-reach test 4.6. Pulmonary function tests 4.7. Cycle ergometer-based graded exercise test (GXT) using a ramp protocol supervised by a rehabilitation/sports medicine physician to collect data on maximal oxygen uptake (VO2 max), anaerobic threshold (AT), and work, etc., to assess cardiorespiratory fitness	—

Measure

Time frame

Measured at baseline and after 12 weeks: 1. Demographic data measured by self report 2. Self-perceived health status measured using the Self-perceived health status scale (Chinese version) 3. Activity measured using the International Physical Activity Questionnaire (IPAQ)-Chinese version short form 4. Objective measurements of health-related physical fitness parameters were performed by a well-trained research assistant: 4.1. Resting heart rate and blood pressure 4.2. Body mass index (BMI) (kg/m²) 4.3. Upper limb grip strength 4.4. Muscular endurance measured using the 30-second chair stand test 4.5. Flexibility measured using the chair sit-and-reach test 4.6. Pulmonary function tests 4.7. Cycle ergometer-based graded exercise test (GXT) using a ramp protocol supervised by a rehabilitation/sports medicine physician to collect data on maximal oxygen uptake (VO2 max), anaerobic threshold (AT), and work, etc., to assess cardiorespiratory fitness

—

Secondary

Measure	Time frame
1. Sleep quality measured using PSQI scale Chinese version at baseline and after 12 weeks 2. Quality of life measured using SF-36 Chinese version at baseline and after 12 weeks	—

Countries

Algeria, American Samoa, Andorra, Angola, Anguilla, Antarctica, Antigua and Barbuda, Argentina, Armenia, Aruba, Taiwan

Contacts

Public ContactYiPang Lo

808010023@mail.ndmctsgh.edu.tw+886-0988-082940

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026