An investigation into the barrier function and barrier forming proteins of the skin in polymorphic light eruption

A non-randomised trial investigating the barrier function and barrier forming proteins of the skin in polymorphic light eruption

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN44480072

Enrollment

Registered

2014-10-29

Start date

2014-02-24

Completion date

Unknown

Last updated

2021-02-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Dermatology

Interventions

Measurements of water loss of the skin will be taken from sun protected buttock skin. To assess sunburn threshold, standard minimal erythemal dose (MED) testing will be performed where another area of

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Healthy volunteers or PLE patients that have reached diagnostic criteria for PLE (through patient questionnaire and clinical diagnosis) 2. White Caucasians of photoreactive skin type I-III 3. Female (not pregnant) or male 30-60 years 4. Volunteers giving written informed consent

Exclusion criteria

Exclusion criteria: 1. People who smoke 2. People with other conditions exacerbated by light 3. People taking photoactive medication 4. People unable to complete the visit requirements of the protocol 5. Inability to comply with all requirements of the protocol 6. History of sunbathing or artificial UV exposure in the previous 3 months 7. History of skin cancer

Design outcomes

Primary

Measure	Time frame
Barrier forming protein function. Timepoint(s): 24h	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026