ACTIB: Assessing Cognitive behavioural Therapy in Irritable Bowel

Conditions

Topic: Primary Care Research Network for England, Oral and Gastrointestinal

McCrone P, Everitt H, Landau S, Little P, Bishop FL, O'Reilly G, Sibelli A, Holland R, Hughes S, Windgassen S, Goldsmith K, Coleman N, Logan R, Chalder T, Moss-Morris R.

2021-07-062 citations

10.1186/s12876-021-01848-9

Integrated GP care for patients with persistent physical symptoms: feasibility cluster randomised trial

Meenal Patel, Kirsty James, Rona Moss‐Morris, Mark Ashworth, Mujtaba Husain et al. (23 authors)

BMC Family Practice2020-10-0711 citations

10.1186/s12875-020-01269-9

Cognitive behavioural therapy for irritable bowel syndrome: 24-month follow-up of participants in the ACTIB randomised trial.

Everitt HA, Landau S, O'Reilly G, Sibelli A, Hughes S, Windgassen S, Holland R, Little P, McCrone P, Bishop FL, Goldsmith K, Coleman N, Logan R, Chalder T, Moss-Morris R.

2019-09-0373 citations

10.1016/s2468-1253(19)30243-2

Assessing telephone-delivered cognitive–behavioural therapy (CBT) and web-delivered CBT versus treatment as usual in irritable bowel syndrome (ACTIB): a multicentre randomised trial

Hazel Everitt, Sabine Landau, Gilly O’Reilly, Alice Sibelli, Stephanie Hughes et al. (15 authors)

Gut2019-04-10196 citations

10.1136/gutjnl-2018-317805

Therapist telephone-delivered CBT and web-based CBT compared with treatment as usual in refractory irritable bowel syndrome: the ACTIB three-arm RCT

Hazel Everitt, Sabine Landau, Paul Little, Felicity L. Bishop, Gilly O’Reilly et al. (15 authors)

Health Technology Assessment2019-04-0136 citations

10.3310/hta23170

Assessing Cognitive behavioural Therapy in Irritable Bowel (ACTIB): protocol for a randomised controlled trial of clinical-effectiveness and cost-effectiveness of therapist delivered cognitive behavioural therapy and web-based self-management in irritable bowel syndrome in adults

Hazel Everitt, Sabine Landau, Paul Little, Felicity L. Bishop, Paul McCrone et al. (10 authors)

BMJ Open2015-07-0139 citations

10.1136/bmjopen-2015-008622

Interventions

495 participants with refractory IBS will be randomised to a high-intensity therapist-delivered CBT (TCBT) + treatment as usual (TAU), or a lower intensity web-based CBT programme (LIBT) + TAU, or TAU

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adults (male and female, 18 years and over) with refractory IBS (clinically significant symptoms defined by a IBS-SSS i.e. >75) 2. Fulfilling ROME III criteria and who have been offered first-line therapies (e.g. anti-spasmodics, anti-depressants or fibre-based medications) but still have continuing IBS symptoms for 12 months or more

Exclusion criteria

Exclusion criteria: Current exclusion criteria as of 05/12/2013: 1. Unexplained rectal bleeding or weight loss 2. Diagnosis of inflammatory bowel disease, coeliac disease, peptic ulcer disease or colorectal carcinoma 3. Unable to participate in CBT due to speech or language difficulties 4. No access to an internet computer to be able to undertake the low intensity CBT, previous access to the MIBS website, received CBT for IBS in the last two years Previous exclusion criteria: 1. Unexplained rectal bleeding or weight loss 2. Diagnosis of inflammatory bowel disease, coeliac disease, peptic ulcer disease or colorectal carcinoma 3. Unable to participate in CBT due to speech or language difficulties 4. No access to an internet computer to be able to undertake the low intensity CBT or previous participation in the MIBS study

Design outcomes

Primary

Measure	Time frame
Current primary outcome measures as of 05/12/2013: 1. IBS Symptom Severity Score (IBS SSS) 2. Work and Social Adjustment Scale (WASAS) Timepoint(s): 3, 6 and 12 months Previous primary outcome measures: 1. The Subjects Global Assessment of Relief (SGA of Relief) 2. IBS Symptom Severity Score (IBS SSS) Timepoint(s): 3, 6 and 12 months	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

United Kingdom

Outcome results

None listed