The influence of the continuous administration of a stimulants (ephedrine or phenylephrine) into a vein on the stability of the blood flow through the heart and blood vessels after the local anesthetic is injected around the spinal cord in the senior adults

The influence of the infusion of ephedrine and phenilephrine on the stability of the circulation after subarachnoidal anesthesia in senior adults

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN44377602

Enrollment

Registered

2017-09-20

Start date

2017-07-01

Completion date

Unknown

Last updated

2019-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subarachnoidal anesthesia Surgery Subarachnoidal anesthesia

Interventions

In the operating theatre, participants are randomised to one of three groups using closed envelope randomisation. Group 1: Participants receive 1000 ml of Ringer solution infusion in

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 50 years and over 2. ASA II-III 3. Patients scheduled for lower extremity surgery

Exclusion criteria

Exclusion criteria: 1. Heart failure (known ejection fraction less than 30%) 2. Manifest heart valve disease 3. Arrythmias 4. Ishaemic heart disease 5. Manifest liver disease 6. Kidney disease (serum creatinine more than 120 mmol/L) 7. BMI more than 30 8. Drug abuse (including alcohol) 9. Chronic use of benzodiazepines, opioids or other psychotropic substances 6. Drug abuse (including alcohol) 7. Chronic use of benzodiazepines, opioids or other psychotropic substances

Design outcomes

Primary

Measure	Time frame
1. Blood pressure is measured using oscylometric measurement with an Aesculon, Osypca Medical, 2011 monitor at baseline for 15 minutes before and 30 minutes after subarachnoidal anaesthesia 2. Cardiac output is measured using thoracic electrical bioimpedancy using an Aesculon, Osypca Medical, 2011 monitor at baseline for 15 minutes before and 30 minutes after subarachnoidal anaesthesia 3. Heart rate frequency is measured using thoracic electrical bioimpedancy using an Aesculon, Osypca Medical, 2011 monitor at baseline for 15 minutes before and 30 minutes after subarachnoidal anaesthesia	—

Measure

Time frame

1. Blood pressure is measured using oscylometric measurement with an Aesculon, Osypca Medical, 2011 monitor at baseline for 15 minutes before and 30 minutes after subarachnoidal anaesthesia 2. Cardiac output is measured using thoracic electrical bioimpedancy using an Aesculon, Osypca Medical, 2011 monitor at baseline for 15 minutes before and 30 minutes after subarachnoidal anaesthesia 3. Heart rate frequency is measured using thoracic electrical bioimpedancy using an Aesculon, Osypca Medical, 2011 monitor at baseline for 15 minutes before and 30 minutes after subarachnoidal anaesthesia

—

Secondary

Measure	Time frame
1. Systemic Vascular Resistance (SSVR) is measured using thoracic electrical bioimpedancy using an Aesculon, Osypca Medical, 2011 monitor at baseline for 15 minutes before and 30 minutes after subarachnoidal anaesthesia 2. Left Cardiac work (LCSW) is measured using thoracic electrical bioimpedancy using an Aesculon, Osypca Medical, 2011 monitor at baseline for 15 minutes before and 30 minutes after subarachnoidal anaesthesia 3. Potential rescue management is recorded for each patient by the investigator at the anesthetic documentation after subarachnoidal anaesthesia	—

Measure

Time frame

1. Systemic Vascular Resistance (SSVR) is measured using thoracic electrical bioimpedancy using an Aesculon, Osypca Medical, 2011 monitor at baseline for 15 minutes before and 30 minutes after subarachnoidal anaesthesia 2. Left Cardiac work (LCSW) is measured using thoracic electrical bioimpedancy using an Aesculon, Osypca Medical, 2011 monitor at baseline for 15 minutes before and 30 minutes after subarachnoidal anaesthesia 3. Potential rescue management is recorded for each patient by the investigator at the anesthetic documentation after subarachnoidal anaesthesia

—

Countries

Slovenia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 20, 2026