Total disc replacement versus fusion in cervical radiculopathy

Total disc replacement versus fusion in cervical radiculopathy: a multicenter randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN44347115

Enrollment

150

Registered

2012-03-19

Start date

2007-05-20

Completion date

Unknown

Last updated

2022-01-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cervical radiculopathy Musculoskeletal Diseases Radiculopathy

Interventions

1. Decompression and fusion of 1-2 cervical levels. Fusion is done with bone graft from iliac crest and anterior plate stabilisation 2. Decompression and disc replacement with Discover

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. At least 3 months of radiculopathy 2. Associated findings on Magnetic resonance imaging (MRI) at 1-2 levels in cervical spine 3. 18-60 years old

Exclusion criteria

Exclusion criteria: 1. Previous cervical surgery 2. Drug abuse or other obvious reason for bad compliance 3. History of Whiplash associated disorder (WAD) or severe cervical trauma 4. Rheumatoid arthritis, known malignancy, active infection or other systemic disease 5. Pregnancy 6. Cervical malformations

Design outcomes

Primary

Measure	Time frame
Neck Disability Index (NDI) at 2 years follow up after intervention	—

Secondary

Measure	Time frame
1. Visual Analaogue Scale (VAS) neck/arm 2. EQ-5D 3. Dysphagia Short Questionnaire (DSQ) 4. Radiographic evaluation 5. Sick leave 6. Consumption of analgetics	—

Countries

Sweden

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026