The symptoms, virology and immunity of COVID in healthcare workers

Longitudinal study of COVID-19: symptoms, virology & immunity

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN44324934

Enrollment

135

Registered

2020-05-18

Start date

2020-04-30

Completion date

Unknown

Last updated

2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19 (SARS-CoV-2 infection) Infections and Infestations

Interventions

1. Online consent, baseline data collection 2. Online daily symptom diary - for 3 months 3. Self-sampling upper respiratory tract (nose, throat & saliva) - twice weekly for 3 months 4. Blood sampling

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Any patient-facing clinical staff member working regularly in the Children’s Emergency Department (CED) of Bristol Royal Hospital for Children, including doctors, nurses and healthcare assistants

Exclusion criteria

Exclusion criteria: 1. Staff who, on average, work less than two shifts per week 2. Staff who anticipate that they will not able to complete at least 6 weeks of the study, excluding annual leave e.g. about to go on maternity leave

Design outcomes

Primary

Measure	Time frame
COVID-19 symptoms measured using online daily symptom diary every day for 3 months	—

Secondary

Measure	Time frame
1. COVID-19 infection measured using self-sampling of upper respiratory tract (nose, throat & saliva) - twice weekly for 3 months 2. Serum antibody levels and peripheral antigen-specific memory T cells measured using blood sampling at weeks 0, 6, 12, 18, and 52	—

Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026