Preterm prelabor rupture of the membranes (PPROM), homecare vs hospital care Pregnancy and Childbirth Preterm prelabor rupture of the membranes (PPROM)
Conditions
Interventions
Women with PPROM before 34+0 weeks of gestation are recruited to this study when they come to hospital. Everyone receives intravenous antibiotics for 3 consecutive days. Amniocentesis is performed to
Sponsors
Helsinki University Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. PPROM at gestational weeks 20+0 to 33+6 2. No clinical signs of infection 3. No subclinical infection in amniocentesis 4. Willing to participate 5. Singleton pregnancy
Exclusion criteria
Exclusion criteria: 1. Severe Intrauterine growth restriction (IUGR) or redistribution in fetal blood flow 2. Symptomatic pre-eclampsia, or pre-eclampsia with blood pressure medication, proteinuria, or abnormal laboratory values 3. Clinical infection in vagina or uterus, or HIV infection 4. Inadequate language skills to understand the written medical consent or handout of the study 5. Diabetes Type 1
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Infectious events in mothers and in neonates during pregnancy and for 2 weeks after birth. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Length of the pregnancy after PPROM 2. Any events in the pregnancy after randomization 3. Apgar scores at 1 min and 5 min after birth and pH values of the neonates 4. Venous and arterial blood pH value for the neonate is measured using blood taken from the umbilical cord immediately after delivery 4. Satisfaction of the mothers. The women will fill the first part of the satisfaction questionnaire immediately after randomization, and the second part at 34+0 weeks of gestation, when an individual plan for the delivery is made, or before that if the delivery starts spontaneously. | — |
Countries
Finland
Outcome results
None listed