Managing Multiple Health Conditions in Older Adults (MODS): Benefiting from activities to help your mood and physical wellbeing

Multimorbidity in Older Adults with Depression Study (MODS): A pragmatic fully-powered randomised controlled trial of usual care compared to a behavioural activation intervention to maintain or improve physical and mental functioning in older adults with long term health conditions and comorbid low mood/depression.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN44184899

Enrollment

572

Registered

2022-08-11

Start date

2022-08-15

Completion date

Unknown

Last updated

2022-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Physical health conditions and co-morbid low mood or depression in older adults. Mental and Behavioural Disorders

Interventions

Participants will be randomly allocated 1:1 to either the behavioural activation intervention group or the usual care group. Active intervention: Behavioural Activation (BA) within a

such activities may benefit their physical and emotional wellbeing by helping people to stay connected with the world and remain active. The practitioner (MODS support worker) and participant work tog

with face-to-face visits as an option where this would facilitate study inclusion and were feasible for the MODS support worker). As part of the collaborative care framework, MODS support workers will

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Older adults aged 65 years or over 2. Two or more long-term physical health conditions 3. Depressive symptoms as indicated by the presence of sub-threshold depression or major depressive disorder, according to the Structured Clinical Interview for DSM-5 Axis 1 disorders depression subscale (SCID).

Exclusion criteria

Exclusion criteria: Older adults who: 1. Have cognitive impairment 2. Have bipolar disorder/psychosis/psychotic symptoms 3. Have alcohol or drug dependence 4. Are in the palliative phase of illness 5. Have active suicidal ideation 6. Are currently receiving psychological therapy 7. Are unable to speak or understand English

Design outcomes

Primary

Measure	Time frame
Self-reported quality of life and functioning (as measured by the Short Form 12 version 2) at 4 months post-randomisation.	—

Secondary

Measure	Time frame
Collected at baseline, 4, 8 and 12 months post-randomisation (unless otherwise stated): 1. Quality of life and functioning (SF12v2) at baseline, 8 and 12 months post-randomisation 2. Depression status according to DSM-5 criteria (SCID-5) 3. Depression severity (PHQ9) 4. Anxiety (GAD7) 5. Physical function (Nottingham Extended Activities of Daily Living Scale) 6. Loneliness (De Jong Gierveld Scale - 11 items) 7. Social Networks and Isolation (Lubben Social Network Scale – 6 items) 8. Health Related Quality of Life (EQ5D-3L) 9. Chronic pain (Graded chronic pain scale revised – two questions) 10. A bespoke questionnaire will be used to collect health service use data.	—

Measure

Time frame

Collected at baseline, 4, 8 and 12 months post-randomisation (unless otherwise stated): 1. Quality of life and functioning (SF12v2) at baseline, 8 and 12 months post-randomisation 2. Depression status according to DSM-5 criteria (SCID-5) 3. Depression severity (PHQ9) 4. Anxiety (GAD7) 5. Physical function (Nottingham Extended Activities of Daily Living Scale) 6. Loneliness (De Jong Gierveld Scale - 11 items) 7. Social Networks and Isolation (Lubben Social Network Scale – 6 items) 8. Health Related Quality of Life (EQ5D-3L) 9. Chronic pain (Graded chronic pain scale revised – two questions) 10. A bespoke questionnaire will be used to collect health service use data.

—

Countries

England, United Kingdom

Contacts

Public ContactLiz Littlewood

liz.littlewood@york.ac.uk01904321828

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026