Effects of gut microbiome and environment on the development of eczema in Chinese infants

Early-life gut microbiome and environmental factors in the development of eczema in Chinese children

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN44080054

Enrollment

1250

Registered

2020-02-29

Start date

2016-11-29

Completion date

Unknown

Last updated

2021-06-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eczema Skin and Connective Tissue Diseases Dermatitis and eczema

Interventions

This will be a prospective birth cohort study of 1,250 Chinese newborns in which parents will be asked to provide demographic data, their infant birth data and allergy condition by questionnaires. Sto

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Full-term infants 2. Chinese ethnicity 3. Resident in Hong Kong

Exclusion criteria

Exclusion criteria: 1. Infants with GI disorders after birth 2. Admitted to neonatal ICU 3. Mothers have fever or an infection or are currently taking antibiotics

Design outcomes

Primary

Measure	Time frame
Gut microbiome diversity profile analysed by 16S sequencing of DNA extracted from the stool at enrolment, 4 months, 1 year and 2 years	—

Secondary

Measure	Time frame
Measured at enrolment, 4 months, 1 year and 2 years: 1. Infant’s allergy condition assessed by the modified parent proxy version of the Comprehensive Early Childhood Allergy Questionnaire 2. The subjects’ dietary factors assessed by a parent proxy dietary practice questionnaire, adopted from the Chinese version of the eating-habit module of the Behavioural Risk Factor Surveillance System 3. Parents’ level of stress assessed by ten-item Perceived Stress Scale	—

Measure

Time frame

Measured at enrolment, 4 months, 1 year and 2 years: 1. Infant’s allergy condition assessed by the modified parent proxy version of the Comprehensive Early Childhood Allergy Questionnaire 2. The subjects’ dietary factors assessed by a parent proxy dietary practice questionnaire, adopted from the Chinese version of the eating-habit module of the Behavioural Risk Factor Surveillance System 3. Parents’ level of stress assessed by ten-item Perceived Stress Scale

—

Countries

Hong Kong

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026