Prevention of recurrence of genital wart lesions after laser and cryotherapy using green tea extract

Conditions

External genital warts Infections and Infestations Anogenital warts

Gaspari V, Cinotti E, Puviani M, Trovato E, Campoli M, Milani M.

2022-02-01

10.23736/s2784-8671.21.06894-2

Efficacy of sinecatechins 10% as proactive sequential therapy of external genital warts after laser CO<sub>2</sub> ablative therapy: The PACT study (post-ablation immunomodulator treatment of condylomata with sinecatechins): a randomized, masked outcome assessment, multicenter trial

Mario Puviani, Marco Galluzzo, Marina Talamonti, Sara Mazzilli, Elena Campione et al. (9 authors)

International Journal of STD & AIDS2018-09-209 citations

10.1177/0956462418797874

Interventions

Veregen (ointment formulation of 10% sinecatechins derived from green tea extract) was applied in the area of condyloma previously treated with laser or cryotherapy. Patients were instructed to apply

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Presence of multiple external genital warts eligible for ablative treatments

Exclusion criteria

Exclusion criteria: 1. HIV-positive subjects 2. Acute inflammatory skin disease

Design outcomes

Primary

Measure	Time frame
Recurrence of new external genital warts at 3 months after the last ablative treatment session	—

Secondary

Measure	Time frame
1. Tolerability 2. Safety profile At each study visit at months 1, 2 and 3, the investigator assessed local skin signs, including erythema, oedema, induration, vesicles, erosion /ulceration, other skin signs and overall skin signs, and the patient was questioned about local skin symptoms, including burning, itching, pain, other skin symptoms and overall skin symptoms. Intensity of all skin reactions at the site of application was graded as: none, mild (local skin reaction which can be easily tolerated), moderate (local skin reaction which is associated with considerable discomfort, but does not prevent usual activity), or severe (local skin reaction which substantially interferes with the patient’s usual activity).	—

Measure

Time frame

1. Tolerability 2. Safety profile At each study visit at months 1, 2 and 3, the investigator assessed local skin signs, including erythema, oedema, induration, vesicles, erosion /ulceration, other skin signs and overall skin signs, and the patient was questioned about local skin symptoms, including burning, itching, pain, other skin symptoms and overall skin symptoms. Intensity of all skin reactions at the site of application was graded as: none, mild (local skin reaction which can be easily tolerated), moderate (local skin reaction which is associated with considerable discomfort, but does not prevent usual activity), or severe (local skin reaction which substantially interferes with the patient’s usual activity).

—

Countries

Italy

Outcome results

None listed