Which is the most effective method of providing non-invasive respiratory support (NIRS) to preterm neonates with lung disease?

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN43771164

Enrollment

Registered

2010-06-24

Start date

2008-11-01

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Respiratory, Generic Health Relevance and Cross Cutting Themes

Interventions

Group 1: Continuous positive airway pressure (CPAP) versus synchronised inspiratory positive airway pressure (SiPAP) Group 2: CPAP versus Optiflow

Eligibility

Inclusion criteria

Inclusion criteria: Not provided at time of registration

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

Measure	Time frame
Provide evidence to allow clinicians to choose the most effective mode of NIRS	—

Secondary

Measure	Time frame
1. Allow standardisation of NIRS equipment and policies across neonatal care networks 2. Optimise work of breathing allowing infants to thrive and wean off NIRS more rapidly 3. Potentially reduce incidence and/or severity of neonatal chronic lung disease, with consequent savings in health care in early life (e.g., home oxygen) 4. Provide information to guide clinicians and managers in purchasing cost-effective equipment 5. Reduce cot days on IPPV allowing more efficient use of resources 6. Reduce likelihood of infant having to be reintubated to receive IPPV	—

Measure

Time frame

1. Allow standardisation of NIRS equipment and policies across neonatal care networks 2. Optimise work of breathing allowing infants to thrive and wean off NIRS more rapidly 3. Potentially reduce incidence and/or severity of neonatal chronic lung disease, with consequent savings in health care in early life (e.g., home oxygen) 4. Provide information to guide clinicians and managers in purchasing cost-effective equipment 5. Reduce cot days on IPPV allowing more efficient use of resources 6. Reduce likelihood of infant having to be reintubated to receive IPPV

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026