Investigation of the effects and mechanisms of action of different wavelengths of ultraviolet B (UVB) radiation in the treatment of psoriasis

Investigation of the effects and mechanisms of action of different wavelengths of ultraviolet B (UVB) radiation in the treatment of psoriasis: a single centre non-randomised treatment trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN43688684

Enrollment

121

Registered

2010-05-12

Start date

2006-10-01

Completion date

Unknown

Last updated

2020-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Skin

Interventions

Compare the apoptotic effect of different wavelengths of UVB in psoriatic epidermis in vivo.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18 years and over, with no sex specific criteria 2. All patients who are prescribed routine UVB (TL01) for their psoriasis at our centre 3. Give informed consent to participate

Exclusion criteria

Exclusion criteria: 1. Aged under 18 years 2. Systemic immunosupression within 3 months 3. UVB exposure to lower back within 3 months of recruitment 4. Topical treatments other than emollients for 2 weeks

Design outcomes

Primary

Measure	Time frame
Whether the number of apoptotic cells seen within the epidermis is sufficient to allow plaque remodelling. Measured up to 48 hours (4 hours, 8 hours, 12 hours,15 hours, 18 hours, 24 hours, and 48 hours).	—

Secondary

Measure	Time frame
1. Effect of skin type 2. UV dose 3. Age and gender Measured up to 48 hours (4 hours, 8 hours, 12 hours,15 hours, 18 hours, 24 hours, and 48 hours).	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026