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Trial of intensified versus standard medical therapy in elderly patients with congestive heart failure

Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN43596477
Enrollment
820
Registered
2005-09-23
Start date
2002-12-01
Completion date
Unknown
Last updated
2018-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Congestive heart failure Circulatory System Congestive heart failure

Interventions

Medical therapy of congestive heart failure as defined in current guidelines, either guided by symptoms only or symptoms and NT-BNP levels

Sponsors

University Hospital Basel (Switzerland)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Heart failure patients aged greater than 60 years 2. New York Heart Association (NYHA) greater than or equal to II 3. CHF hospitalisation within last year 4. NT-BNP level greater than 800 pg/ml (greater than or equal to 75 years), 400 pg/ml (60 - 74 years)

Exclusion criteria

Exclusion criteria: 1. Serum creatinine greater than 220 µmol/l 2. Valve disease needing surgery 3. Disease other than cardiovascular limiting life-expectancy less than 3 years 4. No informed consent

Design outcomes

Primary

MeasureTime frame
1. All cause hospitalisation free survival after 18 months 2. Quality of life after 18 months

Secondary

MeasureTime frame
1. Primary endpoints after 12 months 2. Components of primary endpoints 3. Overall costs and use of health care resources 4. Cost-effectiveness 5. Patients' preferences regarding treatment 6. Effects of baseline characteristics on outcome 7. Prediction of tolerability and effect of medication

Countries

Switzerland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 4, 2026