The influence of methylenetetrahydrofolate reductase C677T genotype and folate status on deoxyribonucleic acid methylation and uracil misincorporation in the colon of healthy volunteers

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN43577261

Enrollment

Registered

2006-10-06

Start date

2006-09-11

Completion date

Unknown

Last updated

2020-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer Cancer Colorectal cancer

Interventions

400 µg per day folic acid or placebo for three months.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: No lesions detected on full colonoscopy

Exclusion criteria

Exclusion criteria: 1. Colorectal polyps or cancer discovered at present colonoscopy 2. Current or previous diagnosis of cancer, or a strong family history of colorectal cancer or adenomatous polyposis coli 3. Inflammatory bowel disease 4. Current or past history of gluten-sensitive enteropathy 5. Clinical and/or laboratory evidence of intestinal malabsorption 6. Significant renal or liver disease 7. Pregnancy 8. Epilepsy 9. Alcoholism 10. Pernicious anaemia 11. Serum vitamin B12 levels less than 180 ng/l and the use of medication known to antagonise the metabolism of folate

Design outcomes

Primary

Measure	Time frame
Changes in genomic and gene specific DNA methylation and uracil misincorporation.	—

Secondary

Measure	Time frame
Changes in blood and tissue folate and plasma homocysteine.	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026